recent publications

Recent Publications

1. Clarke RA1,2,3*, Siddiqui KS4, Cohen-Hyams T2, Fang Z1,2, Eapen V1,2,3, Walker AK5,6, Killingsworth M7, Bridge WJ4 (2024). Immp2l regulates mitochondrial size, NAD+ biosynthesis and autistic-like behaviour. 2024.

2. Clarke RA*, Govindaraju H, Beretta M, Olzomer E, Lawther A, Walker AK, Fang Z, Eapen V, Cohen-Hyams T, Killingsworth M, Bridge WJ, Turner N, Siddiqui KS* (2024). Immp2l enhances the structure and function of mitochondrial Gpd2 dehydrogenase.  International Journal of Molecular Science, 2024. Jan 12;25(2):990. doi: 10.3390/ijms25020990.

3. Lawther AJ, Zieba J, Fang Z, Furlong TM, Conn I, Govindaraju H, Choong LL, Turner N, Siddiqui KS, Bridge W, Merlin S, Cohen-Hyams T, Killingsworth M, Eapen V, Clarke RA* and Walker AK* (2023). Antioxidant behavioural phenotype in the Immp2l gene knockout mouse.Genes 2023 August 28;14(9):1717. *Senior Authors.

4.  Leung BK, Merlin S, Walker AK, Lawther AJ, Paxinos G, Eapen V, Clarke RA, Balleine BW, Furlong TM (2023). Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder. Behavioural Brain Research 452, 2023, 114610.

5. Mortlock DP, Fang ZM, Chandler KJ, Hou Y, Bickford LR, de Bock CE, Eapen V, Clarke RA (2022). Transcriptional Interference Regulates the Evolutionary Development of Speech. Genes 2022 July 4; 13(7) 1195.

6. Fang ZM, Eapen V and Clarke RA (2021). siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference. Genes 2021. Aug 23; 12(8) 1290.

7. Clarke RA, Eapen V (2021). LRRTM4 Terminal Exon Duplicated in Family with Tourette Syndrome, Autism and ADHD. Genes 2021 December 27; 13(1):66.

8. Clarke RA, Furlong T, Eapen V (2021). Tourette Syndrome Risk Genes Regulate Mitochondrial Dynamics, Structure, and Function. Frontiers in Psychiatry 2021 March 10;11.

9. Kreilaus F, Chesworth R, Eapen V, Clarke RA, Karl T (2019). First behavioural assessment of a novel Immp2l knockdown mouse model with relevance for Gilles de la Tourette syndrome and autism spectrum disorder. Brain Research 2019. Nov 18; 374.

10. Fang ZM, Eapen V and Clarke RA (2017). CTNNA3’s discordant regulation of nested LRRTM3 – implications for autism spectrum disorder and Tourette syndrome. Meta Gene, 2017. 11:43-48. [Epub ahead of print] #MGENE-D-16-00119R1.

11. Gokoolparsadh A, Fang Z, Nguyen M, Braidy N, Lin P, Pardy C, Eapen V, Clarke RA, Voineagu I (2017). Transcriptional response to mitochondrial protease IMMP2L knockdown in human astrocytes (2017). Biochem Biophys Res Commun 2017 Jan 22;482(4):1252-1258. doi: 10.1016/j.bbrc.2016.12.024. Epub 2016 Dec 5.

12. Moselhy H, Eapen V, Akawi NA, Younis A, Salih B, Othman AR, Yousef S, Clarke RA, Ali BR (2015). Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients. Meta Gene, Jul 21; 5:135-9. doi: 10.1016/j.mgene, 2015.

13. Clarke RA and Eapen V (2014). Balance within the neurexin trans-synaptic connexus stabilizes behavioural control. Frontiers in Human Neuroscience (2014). Feb 27;8:52|doi: 10.3389/fnhum.2014.00052

14. Eapen V and Clarke RA (2014). Autism spectrum disorders: from genotypes to phenotypes. Frontiers in Human Neuroscience 2014 Nov12;8:914.

15. Clarke RA, Lee S, Eapen V (2012). Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism (2012).  Translational Psychiatry Sept, e158; doi:10.1038/tp.2012.75. * Seminal paper in the field describing the first integrated pathogenetic model for Tourette syndrome.